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PD1-PDL1 inhibitor 1

CAS No. 1675201-83-8

PD1-PDL1 inhibitor 1( PD-1/PD-L1 inhibitor 1 )

Catalog No. M12558 CAS No. 1675201-83-8

PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PD1-PDL1 inhibitor 1
  • Note
    Research use only, not for human use.
  • Brief Description
    PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
  • Description
    PD1-PDL1 inhibitor 1 (CAS 1675201-83-8) is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:NK cells and HepG2 cells Concentration:1 μM Incubation Time:3 days Result:Disturbed the interaction between PD-1 and PD-L1.
  • In Vivo
    Animal Model:BALB/c mice with EMT6 cells Dosage:500 μg/mL; 100 μL Administration:I.p.Result:Increased the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group.mVEGF165b combined with MUC1 results significant retardation of the tumor growth.
  • Synonyms
    PD-1/PD-L1 inhibitor 1
  • Pathway
    Immunology/Inflammation
  • Target
    PD-1/PD-L1
  • Recptor
    PD-1/PD-L1
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1675201-83-8
  • Formula Weight
    475.576
  • Molecular Formula
    C29H33NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    O=C([C@H]1N(CC2=C(OC)C=C(OCC3=CC=CC(C4=CC=CC=C4)=C3C)C=C2OC)CCCC1)O
  • Chemical Name
    2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).
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